The Effectiveness of a Systemic Therapy–Based Intervention on Reducing Anxiety and Increasing Hope in Life among Patients with Thalassemia
Keywords:
Thalassemia, Systemic Therapy, Anxiety, Hope in Life, Family TherapyAbstract
Objective: This study aimed to examine the effectiveness of a systemic therapy–based intervention in reducing anxiety and increasing hope in life among patients with thalassemia.
Methodology: This applied study used a quasi-experimental pretest–posttest design with a control group and a follow-up phase. The population consisted of patients with thalassemia aged 10–30 years in Zahedan, from whom 30 participants were purposively selected and randomly assigned to experimental and control groups. The experimental group participated in eight group sessions of systemic therapy with family involvement. Anxiety and hope were assessed using standardized questionnaires, and data were analyzed using analysis of covariance and repeated-measures ANOVA.
Findings: Analysis of covariance indicated a significant reduction in anxiety (F=10.527, p=0.003) and a significant increase in hope in life (F=35.293, p<0.001) in the experimental group compared to the control group. Repeated-measures ANOVA revealed significant time and time×group interaction effects for both variables (p<0.05), and Bonferroni post hoc tests confirmed the stability of treatment effects at follow-up.
Conclusion: Systemic therapy–based intervention is an effective and sustainable approach for reducing anxiety and enhancing hope in life among patients with thalassemia.
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Aydin, B., Yaprak, I., Akarsu, D., ÖKten, N., & üLgen, M. (1997). Psychosocial aspects and psychiatric disorders in children with thalassemia major. Pediatrics International, 39(3), 354-357. https://doi.org/10.1111/j.1442-200X.1997.tb03752.x
Carr, A. (2025). Family therapy and systemic interventions for child‐focussed problems: The evidence base. Journal of Family Therapy, 47(1), e12476. https://doi.org/10.1111/1467-6427.12476
Farahnaz, K., Mokhtar, A., & Hassan, A. (2021). Comparative Effectiveness of Bowen Family Therapy and Acceptance and Commitment Therapy (ACT) on the Differentiation of Mothers with Only One Child. Journal of Islamic-Iranian Family Studies, 1(1), 31-44. https://magiran.com/p2457503
Ghavanati, J. F., Ehteshami, Z., & Parvin. (2025). Effectiveness of Emotion-Based Group Family Therapy on Self-Differentiation and Alexithymia in Adolescent Girls with Psychosomatic Disorders. Scientific Journal of Ruyesh Psychology, 13(9), 121-130. https://frooyesh.ir/article-1-5385-fa.html
Ghorbanpoor, M., Mirzaie, M., Mirhaghjou, S. N., & Atrkar Roshan, Z. (2020). The relationship between psychosocial status and adherence to treatment regimen in adolescents with thalassemia. Journal of Holistic Nursing And Midwifery, 30(2), 78-85. https://doi.org/10.32598/jhnm.30.2.78
Heatherington, L., Friedlander, M. L., Diamond, G. M., Escudero, V., & Pinsof, W. M. (2014). 25 Years of systemic therapies research: Progress and promise. Psychotherapy Research, 25(3), 348-364. https://doi.org/10.1080/10503307.2014.983208
Hemmatipour, A., Rokhafrooz, D., Ghahfarokhi, S. M. R., & Mirmoghtadaie, Z. (2024). Effect of Family-Centered Empowerment Model Using Mobile Learning on the Quality of Life in Children with Thalassemia: A Quasi-Experimental Study. Jundishapur Journal of Chronic Disease Care, 13(1). https://doi.org/10.5812/jjcdc-138139
Homaei, F., Shahlapour, S., Omidbakhtiari, N., & Mirzaei, Z. (2023a). The Effectiveness of McMaster's Systemic Couple Therapy on Self-Differentiation and Marital Boredom and Intimacy of Couples With Emotional Divorce. Jarac, 5(2), 41-47. https://doi.org/10.61838/kman.jarac.5.2.6
Homaei, F., Shahlapour, S., Omidbakhtiari, N., & Mirzaei, Z. (2023b). The effectiveness of McMaster's systemic couple therapy on self-differentiation and marital boredom and intimacy of couples with emotional divorce. Journal of Assessment and Research in Applied Counseling (JARAC), 5(2), 41-47. https://doi.org/10.61838/kman.jarac.5.2.6
Pakbaz, Z., Treadwell, M., Yamashita, R., Quirolo, K., Foote, D., Quill, L., Singer, T., & Vichinsky, E. P. (2005). Quality of life in patients with thalassemia intermedia compared to thalassemia major. Annals of the New York Academy of Sciences, 1054(1), 457-461. https://doi.org/10.1196/annals.1345.059
Retzlaff, R., von Sydow, K., Beher, S., Haun, M. W., & Schweitzer, J. (2013). The efficacy of systemic therapy for internalizing and other disorders of childhood and adolescence: A systematic review of 38 randomized trials. Family Process, 52(4), 619-652. https://doi.org/10.1111/famp.12041
Robinson, R. (2025). Systemic family therapy through the eyes of a clinical psychology trainee in 2024: History, context and clinical application. Human Systems. https://doi.org/10.1177/26344041251319529
Salehi, M., Abkenar, B. N., & Rashidi, T. (2024). The Effectiveness of Gottman's Systemic Cognitive Couple Therapy on Marital Conflicts, Communication Patterns, and Alexithymia in Couples With Marital Conflict. Jarac, 6(3), 145-152. https://doi.org/10.61838/kman.jarac.6.3.16
Sefidari, L., Mohammadzadeh Ebrahimi, A., & Hematafza, P. (2022). The Effectiveness of Bowen's Systemic Family Therapy on Chronic Anxiety and Differentiation in Patients with Psychosomatic Disorders. Journal of Psychological Science, 21(115), 1375-1390. https://doi.org/10.52547/JPS.21.115.1375
Shafique, F., Ali, S., Almansouri, T., Van Eeden, F., Shafi, N., Khalid, M., Khawaja, S., & Andleeb, S. (2021). Thalassemia, a human blood disorder. Brazilian Journal of Biology, 83(8). https://medpip.com/mag/%D8%A8%DB%8C%D9%85%D8%A7%D8%B1%DB%8C-%D8%AA%D8%A7%D9%84%D8%A7%D8%B3%D9%85%DB%8C/
Silvestre, M., & Tarquinio, C. L. (2022). Systemic family therapy and EMDR therapy: An integrative approach. European Journal of Trauma & Dissociation, 6(4), 100291. https://doi.org/10.1016/j.ejtd.2022.100291
von Sydow, K., Retzlaff, R., Beher, S., Haun, M. W., & Schweitzer, J. (2013). The efficacy of systemic therapy for childhood and adolescent externalizing disorders: A systematic review of 47 RCT. Family Process, 52(4), 576-618. https://doi.org/10.1111/famp.12047
Wang, M., Huang, M., & Hong, Y. (2022). Psychological intervention in children with transfusion‐dependent β‐thalassaemia. Vox Sanguinis, 117(3), 386-392. https://doi.org/10.1111/vox.13201
Zahra, R. n., Ali Akbar, S., Ali Mohammadzadeh, E., & Mehdi Ghasemi, M. (2023). Comparative Effectiveness of Bowen Systemic Therapy and Combined Bowen Systemic Therapy with Neurofeedback on Reducing Anxiety Levels in Students. Journal of Knowledge and Research in Applied Psychology, 24(94), 227-244. https://magiran.com/p2703803
Zamanifar, M., Keshavarzi, F., Hassani, F., & Emamipour, S. (2022). Comparing effectiveness of cognitive-behavioral couple therapy with systemic-behavioral couple therapy on intimacy and differentiation of self in couples with marital conflict. Journal of Psychological Science, 21(117), 1779-1798. https://doi.org/10.52547/JPS.21.117.1779
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