Comparison of Sexual Dysfunctions Between Buprenorphine and Opium Users
Keywords:
Sexual disorders, buprenorphine, opium, sexual functionAbstract
Objective: This study aims to compare the sexual dysfunctions associated with buprenorphine and opium use in individuals with substance dependence.
Methodology: A systematic review methodology was employed. Scholarly articles were retrieved from reputable databases including PubMed, Scopus, Web of Science, and Google Scholar using keywords such as Buprenorphine, Opium, Sexual Dysfunction, Libido, and Erectile Dysfunction. Studies involving both human and animal models examining the impact of these substances on sexual function were included. Studies with insufficient or unusable data were excluded from analysis.
Findings: The review revealed that both buprenorphine and opium significantly affect sexual functioning. Buprenorphine, acting on opioid receptors and reducing dopamine and testosterone levels, is associated with decreased libido, erectile dysfunction, and orgasmic difficulties. Opium, while temporarily enhancing sexual desire in short-term use, leads to diminished sexual responsiveness, orgasmic delay, premature ejaculation, and reduced sperm quality in chronic use. Psychological dysfunctions such as sexual anxiety, depression, and stress were also commonly observed in users of both substances. Notably, buprenorphine may induce more persistent central nervous system suppression, while opium tends to cause more acute hormonal disruptions.
Conclusion: Sexual dysfunctions linked to buprenorphine and opium use result from a complex interplay of hormonal, neurological, and psychological mechanisms. Long-term use of either substance can have enduring negative consequences on sexual health. Comparative insights into these effects are essential for selecting appropriate treatment strategies and optimizing therapeutic interventions in addiction recovery.
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