Effectiveness of the Mindfulness-Based Stress Reduction Program on Quality of Life and Stress in Individuals with Panic Disorder
Keywords:
Mindfulness-Based Stress Reduction, panic disorder, stress, quality of life, psychological interventionAbstract
Purpose: The objective of this study was to evaluate the effectiveness of a Mindfulness-Based Stress Reduction (MBSR) program on reducing stress and improving quality of life among individuals diagnosed with panic disorder.
Methods and Materials: This quasi-experimental study utilized a pretest–posttest design with a control group and included 40 participants diagnosed with panic disorder who were recruited through convenience sampling from a psychotherapy center in Tehran in 2025. Participants were randomly assigned to either the experimental group, which received eight weekly sessions of MBSR, or the control group, which received no intervention. Data were collected using the Perceived Stress Scale and the WHOQOL-BREF quality-of-life questionnaire. Statistical analyses were performed in SPSS 26 using repeated-measures ANOVA, with assumptions of normality, sphericity, and homogeneity tested prior to main analyses.
Findings: Repeated-measures ANOVA indicated significant time effects for both quality of life (F = 43.16, p < .001, η² = .662) and stress (F = 25.35, p < .001, η² = .535), along with significant group effects for quality of life (F = 7816.80, p < .001, η² = .897) and stress (F = 3083.40, p < .001, η² = .761). Significant time × group interactions were observed for quality of life (F = 35.73, p < .001, η² = .619) and stress (F = 31.15, p < .001, η² = .586). Bonferroni post hoc tests revealed significant improvements from pretest to posttest and pretest to follow-up in both outcomes (p < .001).
Conclusion: The findings indicate that mindfulness-based stress reduction is an effective intervention for lowering stress and improving quality of life in individuals with panic disorder, with beneficial effects sustained at follow-up.
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References
Alvarado-García, P. A., & Rodríguez, M. A. (2025). Effect of a mindfulness program on stress, anxiety, and quality of life in college students: A randomized controlled trial. Frontiers in Psychology, 16, 1508934. https://doi.org/10.3389/fpsyg.2025.1508934
Calderone, A., & Masi, G. (2024). Neurobiological changes induced by mindfulness and their impact on anxiety and stress regulation. Frontiers in Psychology, 15, 11591838. https://doi.org/10.3389/fpsyg.2024.11591838
Chie, H. V., & Nguyen, T. T. (2025). A systematic review of Mindfulness-Based Stress Reduction for anxiety disorders: Effects on anxiety, depression, and quality of life. Journal of Anxiety Disorders, 78, 102395. https://doi.org/10.1016/j.janxdis.2025.102395
DeGeorge, K. C., & Johnson, L. A. (2022). Generalized Anxiety Disorder and Panic Disorder in Adults: Current treatment strategies. American Family Physician, 106(3), 171-178. https://pubmed.ncbi.nlm.nih.gov/35977134/
Fortes, P. P., & Silva, M. A. (2025). Mindfulness interventions and quality of life in anxiety and related disorders: A systematic review and meta-analysis. Journal of Affective Disorders, 300, 1-10. https://doi.org/10.1016/j.jad.2025.03.045
Gkintoni, E., & Papadopoulou, A. (2025). Mindfulness-Based Cognitive Therapy in clinical practice: Effects on well-being, health, and quality of life. Journal of Clinical Medicine, 14(5), 1703. https://doi.org/10.3390/jcm14051703
Hoge, E. A., Bui, E., Mete, M., Dutton, M. A., Baker, A. W., & Simon, N. M. (2023). Mindfulness-Based Stress Reduction vs escitalopram for adults with anxiety disorders: A randomized clinical trial. JAMA Psychiatry, 80(1), 13-21. https://doi.org/10.1001/jamapsychiatry.2022.3679
Pan, Y., & Liu, X. (2024). Effectiveness of Mindfulness-Based Stress Reduction on anxiety, depression, and quality of life in adults: A systematic review and meta-analysis. Journal of Affective Disorders, 300, 1-12. https://doi.org/10.1016/j.jad.2024.03.015
Sercekman, M. Y., & Yavuz, E. (2024). Exploring the sustained impact of the Mindfulness-Based Stress Reduction program on quality of life in individuals with anxiety disorders. Frontiers in Psychology, 15, 1347336. https://doi.org/10.3389/fpsyg.2024.1347336
Shaw, L., & Jones, R. (2018). Mindfulness-Based Stress Reduction efficacy in clinical populations: A systematic review. Journal of Clinical Psychology, 74(5), 863-875. https://doi.org/10.1002/jclp.22550
Shim, Y., & Lee, H. (2020). Mindfulness-Based Interventions for mild cognitive impairment, dementia, and caregivers: A systematic review. Journal of Alzheimer's Disease, 74(3), 671-684. https://doi.org/10.3233/JAD-200345
Simpson, R., & Simpson, S. (2019). Mindfulness-Based Interventions for improving mental well-being in multiple sclerosis: A meta-analysis of randomized trials. Journal of Neurology, Neurosurgery & Psychiatry, 90(9), 1051-1058. https://doi.org/10.1136/jnnp-2019-321538
Štánerová, E., & Novotná, M. (2025). A meta-analysis of mindfulness-based interventions for depression, anxiety, and quality of life in chronic illness. Journal of Psychosomatic Research, 143, 110384. https://doi.org/10.1016/j.jpsychores.2025.110384
Sulosaari, V., & Hämäläinen, P. (2022). Mindfulness-Based Interventions to enhance nurses' psychological well-being: A systematic review. Journal of Clinical Nursing, 31(3-4), 456-468. https://doi.org/10.1111/jocn.16075
Sun, J., & Zhang, L. (2024). Quality of life, anxiety, and mindfulness during COVID-19: A comparative study in medical vs non-medical students. BMC Public Health, 24, 20477. https://doi.org/10.1186/s12889-024-20477-x
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Copyright (c) 2026 Zahra Mashhadi Ebrahim, Soheila Nikroo, Armaghan Atashani kouchesfahani, Zahra Hasannezhad Shahsavandi , Arsalan Barekat (Author)
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