Maher Institute Inc Iranian Journal of Neurodevelopmental Disorders 3115-848X 3 2024 06 01 Comparison of the Effectiveness of Pharmacotherapy With and Without Psycho-Educational Intervention on Executive Functions in Hospitalized Bipolar Patients Comparison of the Effectiveness of Pharmacotherapy With and Without Psycho-Educational Intervention on Executive Functions in Hospitalized Bipolar Patients 151 160 EN ویدا لوشگانی Journal Article 2024 03 06 <p><strong>Purpose: </strong>This study aimed to compare the effectiveness of pharmacotherapy alone versus pharmacotherapy combined with a structured psycho-educational intervention in improving executive functions among hospitalized patients with Bipolar I Disorder.</p> <p><strong>Methods and Materials: </strong>A randomized controlled trial was conducted involving 30 patients diagnosed with Bipolar I Disorder who were hospitalized in psychiatric facilities in Tehran. Participants were randomly assigned to two groups: an experimental group (n = 15) that received both pharmacotherapy and a 15-session psycho-educational intervention, and a control group (n = 15) that received pharmacotherapy alone. Executive functions were measured using three standardized tools: the Wisconsin Card Sorting Test (WCST), Stroop Color and Word Test (SCWT), and Trail Making Test (TMT). Assessments were conducted at pre-test, post-test, and a two-month follow-up. Data were analyzed using repeated-measures ANOVA and Bonferroni post-hoc tests via SPSS version 27.</p> <p><strong>Findings: </strong>Results indicated statistically significant improvements in executive function scores over time in both groups; however, the experimental group showed significantly greater gains across all three measures. Repeated-measures ANOVA revealed significant time × group interaction effects for WCST (F(2, 56) = 25.23, p &lt; .001, η² = .47), SCWT (F(2, 56) = 21.72, p &lt; .001, η² = .44), and TMT (F(2, 56) = 18.91, p &lt; .001, η² = .41). Bonferroni post-hoc tests confirmed that improvements in the experimental group from pre-test to post-test and follow-up were significantly greater than those observed in the control group.</p> <p><strong>Conclusion: </strong>The findings support the superiority of combining psycho-educational interventions with pharmacotherapy in enhancing executive functions in bipolar patients.</p> https://maherpub.com/index.php/jndd/article/download/462/333